Like in many other Monicelli movies, the main theme of Amici miei is friendship, seen from a rather bitter point of view. It tells the story of four middle-aged friends in Florence who organize together idle pranks (called zingarate, "gypsy shenanigans") in a continuous attempt to prolong childhood during their adult life.
Doug Harris is a loveable but socially awkward groom-to-be with a problem: he has no best man. With less than two weeks to go until he marries the girl of his dreams, Doug is referred to Jimmy Callahan, owner and CEO of Best Man, Inc.
Best pals Jason and Daniel indulge in casual flings and revel in their carefree, unattached lives. After learning that the marriage of their friend Mikey is over, they gladly welcome him back into their circle.
In New York City for their annual tradition of Christmas Eve debauchery, three lifelong best friends set out to find the Holy Grail of Christmas parties since their yearly reunion might be coming to an end.
There is a war in the world between the men and the women. A young girl tries to escape this reality and comes to a hidden place where a strange unicorn lives with a family: Sister, Brother, many children and an old woman that never leaves her bed but stays in contact with the world through her radio.
In Montauban in 1944, Julien Dandieu in a surgeon in the local hospital. Frightened by the German army entering Montauban, he asks his friend Francois to drive his wife and his daughter in the back country village where Julien has an old castle.