At a party, someone goes insane and murders three women. Falsely accused of the brutal killings, Jerry is on the run. More bizarre killings continue with alarming frequency all over town. Trying to clear his name, Jerry discovers the shocking truth...people are losing their hair and turning into violent psychopaths and the connection may be some LSD all the murderers took a decade before.
Jeffrey "The Dude" Lebowski, a Los Angeles slacker who only wants to bowl and drink white Russians, is mistaken for another Jeffrey Lebowski, a wheelchair-bound millionaire, and finds himself dragged into a strange series of events involving nihilists, adult film producers, ferrets, errant toes, and large sums of money.
Paul Groves (Peter Fonda), a television commercial director, is in the midst of a personality crisis. His wife Sally (Susan Strasberg) has left him and he seeks the help of his friend John (Bruce Dern), a self-styled guru who's an advocate of LSD. Paul asks John to be the guide on his first "trip". John takes Paul to a "freak-out" at his friend Max's (Dennis Hopper) pad. Splitting the scene, they score some acid from Max and return to John's split-level pad with an indoor pool. Paul experiences visions of sex, death, strobe lights, flowers, dancing girls, witches, hooded riders, a torture chamber, and a dwarf. He panics but John tells him to "go with it, man." Would you trust John?
A country family of five takes in cousin Julia, whose parents recently perished in a car crash. Julia extends her influence over the family and those around them, fooling all except for Rachel, the teenaged girl who knows her cousin is up to no good.