A sharpshooting saddle tramp (Hugh Cardiff) with a price on his head falls for the daughter (Libby) of a wealthy ranch owner. He vows to win enough money in shooting contests to win her father's approval, but when he returns years later, he finds she has married another man who is jealous of her affections. The husband (Vern) tries to have a murder warrant served on the drifter; shoots him in the back and hires a gambler to murder the man. None of these attempts on the drifter's life kills Cardiff. When the Libby leaves Vern, he goes gunning for the drifter, now the star of a Wild West show.
A research scientist (William Hurt) explores the boundaries and frontiers of consciousness. Using sensory deprivation and hallucinogenic mixtures from native American shamans, he explores these altered states of consciousness and finds that memory, time, and perhaps reality itself are states of mind.
Misery is brought to a small group of Sho in the Kalahari desert in the form of a cola bottle. In his quest to throw the evil object over the edge of the earth, Xixo encounters Western "civilization," a haphazard doctor and a tyranical despot.