The plot of Get Lost! concerns the disappearance of Jim Threadgold (Brian Southwood), husband of English teacher Judy Threadgold (Turner). Aided by her colleague, woodwork teacher Neville Keaton (Armstrong), Judy sets out to find out what has happened to her husband. Judy and Neville soon discover the existence of a secret organisation dedicated to assisting people who want to escape the mundanity of their lives and families and just disappear. Although Judy eventually finds her missing husband, she is none too enthusiastic about taking him back and allows him to seek a new life running a fish and chip shop. Her adversarial relationship with Neville blossoms into a love affair.
Phillip Filmore is a naive, 15-year-old, preoccupied with sex, who develops a crush on Nicole Mallow, the new 30-something, French housekeeper and sitter to look after him when Phillip's father is out of town for the summer on a "business" trip.
Cristina is a rich, spoiled princess visiting Rome with her royal parents. The mission of their visit is to marry her off to a super-wealthy corporate type and thereby start to turn around the losses their small kingdom is experiencing in its casino business.