Stevie "Smudger" Smith and his wife Marie are both addicted to drugs; he's also a dealer. The day he 'deals with' another dealer, she gives birth to a baby. The baby appears to be addicted too and Marie decides to give up the habit. Because Stevie doesn't want to give up using and dealing drugs, they take Marie and the baby away from him. The new, tough, social worker Liam Kane tries to get Stevie in his group sessions, by using his violent approach and by telling him it's the only way he'll ever see Marie and the baby back. So there seems to be hope to get Stevie clean, if only he wants to himself. That things aren't that easy is shown by the drugs addicted hooker Gail, who's satisfied with the life she leads.
It’s 1982, and Taeko is 27 years old, unmarried, and has lived her whole life in Tokyo. She decides to visit her family in the countryside, and as the train travels through the night, memories flood back of her younger years: the first immature stirrings of romance, the onset of puberty, and the frustrations of math and boys.
An American, Leopold Kessler (Jean-Marc Barr) goes to post-war Germany in 1945 to work as a railroad conductor for the Zentropa Rail Line instead of going into the Army because he feels its a more valuable thing to do for the state of the world.
Amidst her own personality crisis, southern housewife Evelyn Couch meets Ninny, an outgoing old woman who tells her the story of Idgie Threadgoode and Ruth Jamison, two young women who experienced hardships and love in Whistle Stop, Alabama in the 1920s.