Merlinda is cursed by her Mother after leaving her father on his death bed to be with her rich lover. Abandoned by all she is now pregnant, destitute, and covered in boils. Merlinda gives birth in a Cave to a human daughter and a snake son. The Baby girl is named Madonna. When Madonna grows up she starts turning into a giant murderous snake. Afraid of losing her lover to the monster she is becoming, Modonna is desperate for answers. Together she and her brother she seek out a cure to their damned existence.
Amidst her own personality crisis, southern housewife Evelyn Couch meets Ninny, an outgoing old woman who tells her the story of Idgie Threadgoode and Ruth Jamison, two young women who experienced hardships and love in Whistle Stop, Alabama in the 1920s.
It’s 1982, and Taeko is 27 years old, unmarried, and has lived her whole life in Tokyo. She decides to visit her family in the countryside, and as the train travels through the night, memories flood back of her younger years: the first immature stirrings of romance, the onset of puberty, and the frustrations of math and boys.
It's the lawless future, and renegade biker Harley Davidson (Mickey Rourke) and his surly cowboy buddy, Marlboro (Don Johnson), learn that a corrupt bank is about to foreclose on their friend's bar to further an expanding empire.