On the death of her mother, a young woman in northern England learns that her father is actually her step-father. She embarks on a search for her birth father, finds him running a jazz club in London, and learns a lot of happy and sad things about her family that she didn't know before. The title of the film is the classic jazz piece, "Misterioso," by Thelonious Monk, which features prominently in it.
George Banks is an ordinary, middle-class man whose 21 year-old daughter Annie has decided to marry a man from an upper-class family, but George can't think of what life would be like without his daughter.
Bored with her marriage to burnt out poet turned corporate executive Thierry, Zandalee falls prey to an old friend of her husband, the manipulative and egotistical Johhny and becomes enmeshed in a sensual, passionate and destructive affair.
An American, Leopold Kessler (Jean-Marc Barr) goes to post-war Germany in 1945 to work as a railroad conductor for the Zentropa Rail Line instead of going into the Army because he feels its a more valuable thing to do for the state of the world.
Whilst on a short weekend getaway, Louise shoots a man who had tried to rape Thelma. Due to the incriminating circumstances, they make a run for it and thus a cross country chase ensues for the two fugitives.