Janice is the subject of the town gossips for four reasons: she wears too much lipstick, her hair is too big, she is a single-mother and her two children are strange. Ray (6) is a hellraiser and Tony (9) is autistic. One day, however, Tony sits down at the piano and plays Twinkle Twinkle Little Star, and Janice knows there may be hope for him (and them) yet.
Professor Phillip Brainard, an absent minded professor, works with his assistant Weebo, trying to create a substance that's a new source of energy and that will save Medfield College where his sweetheart Sara is the president.
Two not-too-bright party girls reinvent themselves for their high school reunion. Armed with a borrowed Jaguar, new clothes and the story of their success as the inventors of Post-it notes, Romy and Michele descend on their alma mater, but their façade crumbles quickly.