The film portrays life of New York City's Lower East Side inhabitants. Introvert therapist Betty is befriended with Chinese immigrant Lu Lu, leftist radical Che is also Lu Lu's friend. Italian immigrant and wife of supervisor of building where they all live, Marta, is having an affair with her neighbour Frankie who likes scams. One of his scams goes terribly wrong.
When teen-socialite Kelly Van Ryan (Richards) and troubled bad girl Suzie Toller (Campbell) accuse guidance counselor Sam Lombardo (Dillon) of rape, he's suspended by the school, rejected by the town, and fighting to get his life back.
When a freighter is viciously attacked in the Pacific Ocean, a team of experts -- including biologist Niko Tatopoulos and scientists Elsie Chapman and Mendel Craven -- concludes that an oversized reptile is the culprit.
When guardian angel Seth -- who invisibly watches over the citizens of Los Angeles -- becomes captivated by Maggie, a strong-willed heart surgeon, he ponders trading in his pure, otherworldly existence for a mortal life with his beloved.
Bobby Boucher is a water boy for a struggling college football team. The coach discovers Boucher's hidden rage makes him a tackling machine whose bone-crushing power might vault his team into the playoffs.