Fresh Air, which focuses on ordinary moments of everyday life, is an original hybrid of urban comedy and kitchen-sink drama. It is also a realistic depiction of relationships among lovers, friends, and family in the multi-cultural environment of a big city. The protagonists are three thirty-something housemates with artistic aspirations.
Following a bomb scare in the 1960s that locked the Webers into their bomb shelter for 35 years, Adam now ventures forth into Los Angeles to obtain food and supplies for his family, and a non-mutant wife for himself.
Homer is an orphan who was never adopted, becoming the favorite of orphanage director Dr. Larch. Dr. Larch imparts his full medical knowledge on Homer, who becomes a skilled, albeit unlicensed, physician.