Fluorescerend Bloed is the bleak story of Henk Johan Kwackel, a misunderstood and neglected young musician who leaves his hometown in the country to - followed by a camera crew - seek his recognition and success in the big city. Once he arrives there, his life and career does not get started because of his introverted character. Henk Johan sinks deeper in his mental swamp. Disillusioned he returns to his home base.
When a street-smart FBI agent is sent to Georgia to protect a beautiful single mother and her son from an escaped convict, he is forced to impersonate a crass Southern granny known as Big Momma in order to remain incognito.
Two petty if violent criminals kidnap a girl being paid $1,000,000 to be a surrogate mother. As the baby is for a gangster the pair's demand for money sees several henchmen and assorted other ruthless characters head after them to Mexico.