When a virus leaks from a top-secret facility, turning all resident researchers into ravenous zombies and their lab animals into mutated hounds from hell, the government sends in an elite military task force to contain the outbreak.
With the impending ice age almost upon them, a mismatched trio of prehistoric critters -- Manny the woolly mammoth, Diego the saber-toothed tiger and Sid the giant sloth -- find an orphaned infant and decide to return it to its human parents.
A rare mutation has occurred within the vampire community - The Reaper. A vampire so consumed with an insatiable bloodlust that they prey on vampires as well as humans, transforming victims who are unlucky enough to survive into Reapers themselves.
Joe Enders is a gung-ho Marine assigned to protect a "windtalker" - one of several Navajo Indians who were used to relay messages during World War II because their spoken language was indecipherable to Japanese code breakers.