Trapped in their New York brownstone's panic room, a hidden chamber built as a sanctuary in the event of break-ins, newly divorced Meg Altman and her young daughter Sarah play a deadly game of cat-and-mouse with three intruders - Burnham, Raoul and Junior - during a brutal home invasion.
After his last assignment ended with the death of an innocent woman, a hitman's new job in London is compromised when he is overcome with guilt, and ends up helping a desperate woman who is caught up in a human trafficking operation.
Out of prison after a five-year stretch, jewel thief Tony (Jean Servais) turns down a quick job his friend Jo (Carl Mohner) offers him, until he discovers that his old girlfriend Mado (Marie Sabouret) has become the lover of local gangster Pierre Grutter (Marcel Lupovici) during Tony's absence.
With the impending ice age almost upon them, a mismatched trio of prehistoric critters -- Manny the woolly mammoth, Diego the saber-toothed tiger and Sid the giant sloth -- find an orphaned infant and decide to return it to its human parents.
When a virus leaks from a top-secret facility, turning all resident researchers into ravenous zombies and their lab animals into mutated hounds from hell, the government sends in an elite military task force to contain the outbreak.
Kay and Jay reunite to provide our best, last and only line of defense against a sinister seductress who levels the toughest challenge yet to the MIBs untarnished mission statement: protecting the earth from the scum of the universe.