Dr. Syd has a good practice in the big city but a bad day when her terminal patient finally passes away. Her surgeon boyfriend, who has been sarcastically nick named "Mr. Personality" and "Settle For" by Syd's best friend (Nurse Brenda), takes this opportunity to offer support and destroys it by telling Syd dying is part of life and she'd be a better doctor if she stayed more remote from her patients and, oh, by the way, "can I come over tonight"? He is surprised when she says "not tonight." Brenda tells Syd to get away for a few days and suggests Syd change her mind and go back to her small hometown for her school reunion.
Yuri Orlov is a globetrotting arms dealer. Through some of the deadliest war zones, Yuri struggles to stay one step ahead of a relentless Interpol agent, his business rivals, even some of his customers who include many of the world's most notorious dictators.
After their father (Tim Robbins) is called into work, two young boys, Walter (Josh Hutcherson) and Danny (Jonah Bobo), are left in the care of their teenage sister, Lisa (Kristen Stewart), and told they must stay inside.