Jeff Hannon (Wilk) from the forever away world of Cincinnatti, Ohio has stumbled upon what he believes to be a 25 year old murder in a small Texas town. His ceaseless nightmares compel him to drive to the middle of nowhere town of Bueford, Texas to enlist the local authorities (Asner, Keenan) to help solve the murder mystery and forever put an end to the voices that haunt him. Hannon's own fate soon becomes entwined with the dusty town's long forgotten history.
After their father (Tim Robbins) is called into work, two young boys, Walter (Josh Hutcherson) and Danny (Jonah Bobo), are left in the care of their teenage sister, Lisa (Kristen Stewart), and told they must stay inside.
The sequel to House of 1000 Corpses – the Firefly family are ambushed at their isolated home by Sheriff Wydell and a squad of armed men guns blazing – yet only Otis and his sister, Baby, manage to escape the barrage of bullets unharmed.