JAM (Christian Clavier), a French "master of the universe" is on the brink of a major takeover when he starts suffering from anxiety attacks. His doctor (Lhermite) thinks it is to do with childhood experiences and suggests he searches back in his mind to something that could be the trigger and will prove to be the antidote.
Lincoln Six-Echo is a resident of a seemingly Utopian but contained facility in the year 2019. Like all of the inhabitants of this carefully controlled environment, Lincoln hopes to be chosen to go to the "The Island" - reportedly the last uncontaminated spot on the planet.
After their father (Tim Robbins) is called into work, two young boys, Walter (Josh Hutcherson) and Danny (Jonah Bobo), are left in the care of their teenage sister, Lisa (Kristen Stewart), and told they must stay inside.
When the renegade crew of Serenity agrees to hide a fugitive on their ship, they find themselves in an action-packed battle between the relentless military might of a totalitarian regime who will destroy anything - or anyone - to get the girl back and the bloodthirsty creatures who roam the uncharted areas of space.