In Louisiana, the thirty-five year old single mother Lavina delivers a baby boy and a monster in the evil Whateley House. Ten years later, Dr. Henry Armitage and his assistant Professor Fay Morgan discover that the page 751 of every copy of the Necronomicon is missing and The Black Brotherhood has summoned the gate keeper Yog Sothoth to leave the portal opened to the demons and ancient gods. They invite the arrogant and skeptical Professor Walter Rice that can translate the Necronomicon to help them to seek the book. Meanwhile Lavina's son Wilbur Whateley ages very fast and seeks the missing page to open the portal.
The boredom of small town life is eating Bill Williamson alive. Feeling constrained and claustrophobic in the meaningless drudgery of everyday life and helpless against overwhelming global dissolution, Bill begins a descent into madness.
A taxi driver gets more than he bargained for when he picks up two teen runaways. Not only does the pair possess supernatural powers, but they're also trying desperately to escape people who have made them their targets.
Set in a futuristic world where humans live in isolation and interact through surrogate robots, a cop (Willis) is forced to leave his home for the first time in years in order to investigate the murders of others' surrogates.