"A woman (we never learn her name) was born with a disorder that renders her unable to feel pain. People tell her she is lucky, but she disagrees; from the time she is a child, she spends all her time attempting to make up for the loss of this sensation – by kidnapping and torturing young women.
A cop (Matthew McConaughey) who moonlights as a hit man agrees to kill the hated mother of a desperate drug dealer (Emile Hirsch) in exchange for a tumble with the young man's virginal sister (Juno Temple).
For Nick (Jason Bateman), Kurt (Jason Sudeikis) and Dale (Charlie Day), the only thing that would make the daily grind more tolerable would be to grind their intolerable bosses (Kevin Spacey, Colin Farrell, Jennifer Aniston) into dust.
A mysterious Hollywood stuntman who moonlights as a getaway driver seems to be trying to escape his shady past as he falls for his neighbor - whose husband is in prison and who's looking after her child alone.