Five graduates from different years come together to celebrate their secondary school teacher Master Jude's 80 year-old birthday. Master Jude is a happy-go-lucky bachelor who enlightened them on the matter of sex during their school days. Since all of the five men have marital problems, this is a good time for them to meet and share their grievances. However, during the celebration party held in a hotel, they encounter 5 pretty, sexy young models. They fall for each other and have a love-fest in the hotel.
For Nick (Jason Bateman), Kurt (Jason Sudeikis) and Dale (Charlie Day), the only thing that would make the daily grind more tolerable would be to grind their intolerable bosses (Kevin Spacey, Colin Farrell, Jennifer Aniston) into dust.
A cop (Matthew McConaughey) who moonlights as a hit man agrees to kill the hated mother of a desperate drug dealer (Emile Hirsch) in exchange for a tumble with the young man's virginal sister (Juno Temple).
When Sid accidentally destroys Manny's heirloom Christmas rock and ends up on Santa's naughty list, he leads a hilarious quest to the North Pole to make things right and ends up making things much worse.
A mysterious Hollywood stuntman who moonlights as a getaway driver seems to be trying to escape his shady past as he falls for his neighbor - whose husband is in prison and who's looking after her child alone.