On Christmas day, a bomb explodes in a shopping mall. The explosion was perpetrated by a serial bomber. A 9-year-old boy Kuro Hazama and his mother Mitsuko (Naho Toda) are seriously and transfered to a university hospital. With the elite skills of surgeon Dr. Jontaro Honma (Masachika Ichimura), Kuro survives, but is shocked to learn his mother is in a coma. Dr. Honma tells Tokio that when medical science advances, Michiko might one day awake. Tokio decides then to become a doctor. 15 years later, 24-year-old Kuro is a medical student and his mother is still in a coma. Kuro researches ways to awaken his mother whilst practising medicine without a licence.
A cop (Matthew McConaughey) who moonlights as a hit man agrees to kill the hated mother of a desperate drug dealer (Emile Hirsch) in exchange for a tumble with the young man's virginal sister (Juno Temple).
When Sid accidentally destroys Manny's heirloom Christmas rock and ends up on Santa's naughty list, he leads a hilarious quest to the North Pole to make things right and ends up making things much worse.
Tired of the noise and madness of New York and the crushing conventions of late Eisenhower-era America, itinerant journalist Paul Kemp travels to the pristine island of Puerto Rico to write for a local San Juan newspaper run by the downtrodden editor Lotterman.