After being deported back to his native Canada, once-famous comedian Bob London attempts a Hollywood comeback by enlisting human smugglers to sneak him across the Mexico-US border. Deposited in East LA after a taxing journey, Bob is rejected by his former manager and famous friends and finds himself penniless and alone. He is then adopted by a pair of migrant workers named Gerardo and Luiz who resolve to show Bob how to make it in America.
Following the death of District Attorney Harvey Dent, Batman assumes responsibility for Dent's crimes to protect the late attorney's reputation and is subsequently hunted by the Gotham City Police Department.
After being held in a coma-like state for fifteen years, vampire Selene learns that she has a fourteen-year-old vampire/Lycan hybrid daughter named Nissa, and when she finds her, they must stop BioCom from creating super Lycans that will kill them all.