Muthu,Senthil,Asim,Munna,Thenali and Kumar are six friends who aspire to become a director, cinematographer, music director, lyricist, hero and comedian. They are tenants at Devadharshini's place and they hunt for opportunities. Opportunity keeps evading them and they are often tricked by money racketing fake production houses. After many such dejections they get a chance to make a movie through a Production Manager (Thambi Ramayya). Whether they make use of the opportunity and make a movie and realise their dreams is 'Thiraipada Nagaram'.
A dramatic thriller based on the incredible true David vs. Goliath story of American immigrant Dr. Bennet Omalu, the brilliant forensic neuropathologist who made the first discovery of CTE, a football-related brain trauma, in a pro player and fought for the truth to be known.