Apocalypse Dreams tells the story of "Rainbow", a down on his luck stoner that returns to NYC after a spiritual retreat to Eurasia. He runs into some old friends and meets "Uma", a struggling writer who also has a weird past and has made some questionable decisions herself. Naturally, love happens, and soon enough Rainbow and Uma are on a mission to right some wrongs and hopefully get drunk or high in the process.
After supervillain Shredder (Brian Tee) escapes custody, he joins forces with mad scientist Baxter Stockman (Tyler Perry) and two dimwitted henchmen, Bebop (Gary Anthony Williams) and Rocksteady (Stephen "Sheamus" Farrelly), to unleash a diabolical plan to take over the world.
The epic story of the first contact, encounter, approach, betrayal and, eventually, life-transcending friendship, between Karamakate, an Amazonian shaman, last survivor of his people, and two scientists that, over the course of 40 years, travel through the Amazon in search of a sacred plant that can heal them.