Billie, a twenty something burnout, is tasked with house-sitting for her aunt and uncle, but after inviting some friends over, becomes convinced her teenage cousin Grace has stolen a notebook containing her latest screenplay. While hunting for the book in "Grace's Room", the gang uncovers a bloody trove of occult paraphernalia. Unbeknownst to Billie and her friends, said cult has been watching them from the nearby woods, and now must kill them for discovering too much. A gruesome assault on the house ensues as the gang struggles to survive the night.
The epic story of the first contact, encounter, approach, betrayal and, eventually, life-transcending friendship, between Karamakate, an Amazonian shaman, last survivor of his people, and two scientists that, over the course of 40 years, travel through the Amazon in search of a sacred plant that can heal them.
Set in the Aokigahara Forest, a real-life place in Japan where people go to end their lives. Against this backdrop, a young American woman comes in search of her twin sister, who has mysteriously disappeared.