A gang of cold-blooded outlaws narrowly escapes a blood-soaked bank robbery in a grimy frontier town. With a notorious bounty hunter hot on their trail, these nefarious criminals desperately need a place to hide out before night falls. Fate brings them to the home of the Tildons, a seemingly innocent family with two feisty daughters. As the men settle in, an impetuous game of cat and mouse plays out during the cold, black night. Come morning, nothing will ever be the same.
There are many things in life that could do a number on a man's masculinity. Lenny Babbitt has his identity and manhood challenged when his wife Tracy leaves him for a female doctor named Iris who has been treating their autistic son Isaac.
After supervillain Shredder (Brian Tee) escapes custody, he joins forces with mad scientist Baxter Stockman (Tyler Perry) and two dimwitted henchmen, Bebop (Gary Anthony Williams) and Rocksteady (Stephen "Sheamus" Farrelly), to unleash a diabolical plan to take over the world.
The epic story of the first contact, encounter, approach, betrayal and, eventually, life-transcending friendship, between Karamakate, an Amazonian shaman, last survivor of his people, and two scientists that, over the course of 40 years, travel through the Amazon in search of a sacred plant that can heal them.