Failed writer Ryan is a man on the edge. Alone and broke, with an estranged wife and mounting debt, he attempts to earn some quick cash by agreeing to pen a short story for a magazine. With the deadline just hours away he heads to a local café and, inspired by the young waitress and the customers around him, cooks up a love story tinged with cynicism.
There are many things in life that could do a number on a man's masculinity. Lenny Babbitt has his identity and manhood challenged when his wife Tracy leaves him for a female doctor named Iris who has been treating their autistic son Isaac.
The epic story of the first contact, encounter, approach, betrayal and, eventually, life-transcending friendship, between Karamakate, an Amazonian shaman, last survivor of his people, and two scientists that, over the course of 40 years, travel through the Amazon in search of a sacred plant that can heal them.