Four friends who are all students, wake up at the police station, not remembering the events of yesterday. They are accused of murdering a dwarf, whose body was found on the lawn of the house where the boys partied last night. To figure out what happened, the boys decide to collect all the photos and videos from yesterday's mayhem.
There are many things in life that could do a number on a man's masculinity. Lenny Babbitt has his identity and manhood challenged when his wife Tracy leaves him for a female doctor named Iris who has been treating their autistic son Isaac.
After supervillain Shredder (Brian Tee) escapes custody, he joins forces with mad scientist Baxter Stockman (Tyler Perry) and two dimwitted henchmen, Bebop (Gary Anthony Williams) and Rocksteady (Stephen "Sheamus" Farrelly), to unleash a diabolical plan to take over the world.
The epic story of the first contact, encounter, approach, betrayal and, eventually, life-transcending friendship, between Karamakate, an Amazonian shaman, last survivor of his people, and two scientists that, over the course of 40 years, travel through the Amazon in search of a sacred plant that can heal them.