The film follows John Crenshaw as he accompanies his girlfriend and her students on a weekend nature-photography expedition deep into the woods. What should be an educational and fun-filled weekend turns into horror as the group is besieged by an unspeakable evil - a horde of hideously disfigured, mutated humans with an insatiable taste for blood. As things go from bad to worse, Crenshaw becomes their only hope if they are going to get out alive.
After supervillain Shredder (Brian Tee) escapes custody, he joins forces with mad scientist Baxter Stockman (Tyler Perry) and two dimwitted henchmen, Bebop (Gary Anthony Williams) and Rocksteady (Stephen "Sheamus" Farrelly), to unleash a diabolical plan to take over the world.
The epic story of the first contact, encounter, approach, betrayal and, eventually, life-transcending friendship, between Karamakate, an Amazonian shaman, last survivor of his people, and two scientists that, over the course of 40 years, travel through the Amazon in search of a sacred plant that can heal them.
After her outlaw husband returns home shot with eight bullets and barely alive, Jane reluctantly reaches out to an ex-lover who she hasn't seen in over ten years to help her defend her farm when the time comes that her husband's gang eventually tracks him down to finish the job.