Carla and Marco are manic-depressive poets whose art is fueled by their emotional extremes. When they go off their meds, they end up in the same psychiatric hospital. As the chemistry between them stirs up their emotions, it intensifies their mania. Despite doctors' and parents' attempts to separate them, they pursue their beautiful but destructive romance which swings them from fantastical manic highs to suicidal depressive lows, until they have to choose between sanity and love.
The epic story of the first contact, encounter, approach, betrayal and, eventually, life-transcending friendship, between Karamakate, an Amazonian shaman, last survivor of his people, and two scientists that, over the course of 40 years, travel through the Amazon in search of a sacred plant that can heal them.
New York City is full of lonely hearts seeking the right match, and what Alice, Robin, Lucy, Meg, Tom and David all have in common is the need to learn how to be single in a world filled with ever-evolving definitions of love.