Fired for crashing his aeroplane into his employer's ranch, Tom Mix is elected sheriff in a town with, as a title stated, "a high mortality rate among sheriffs.
On a train bound for New York, where she hopes to find work, Honey McNeil captures the appreciative eye of William Ogden, a financier, who offers her a job.
When his master is attacked and left speechless, Ranger is held responsible. On the lam from the Law, the canine hero links up with telegrapher Bill Brady and Bill's girlfriend Helen Meadows.
The film was created as a compilation of footage that was, in some cases, nearly fifteen years old, and included stock footage such as medical reels containing footage of venereal diseases and films depicting white slavery.