Carrie Snyder is a prostitute, who is forced out of the fictional southern town of Crebillon, after forming a friendship with a young boy named Paul, whose dying mother is unable to protest against her son visiting such a woman.
Although Larry "Buster" Crabbe earns top billing, the hero of Drift Fence is former Western star Tom Keene as Jim Travis, who, at a rodeo, meets city dweller Jim Traft, who has come west to erect a fence that will prevent Clay Jackson from continuing his cattle rustling business.
A retired Scotland Yard detective, Patrick Fitzpatrick (Tom Walls) comes back to take one final case, tracking down a missing vase which has been stolen by a gang of thieves specialising in taking art treasures.