Dr. Incarnate, is the leader of a terrorist organization that uses scientific methods to turn people into beasts. He also creates giants six feet tall and dwarfs six inches tall.
Although Larry "Buster" Crabbe earns top billing, the hero of Drift Fence is former Western star Tom Keene as Jim Travis, who, at a rodeo, meets city dweller Jim Traft, who has come west to erect a fence that will prevent Clay Jackson from continuing his cattle rustling business.
A retired Scotland Yard detective, Patrick Fitzpatrick (Tom Walls) comes back to take one final case, tracking down a missing vase which has been stolen by a gang of thieves specialising in taking art treasures.
Hoping to rid a small western community of its corrupt political machine, Ken Marshall (Ken Maynard) runs for sheriff against the bad guys' candidate and wins the election.