Irene is unhappy because her lawyer husband Dr. Leuttern never has time for her. Womanizer Mac Norris slyly benefits from her depression and lures her to his apartment. As she struggles to fend him off a shot is fired and Mac collapses.
Hoping to rid a small western community of its corrupt political machine, Ken Marshall (Ken Maynard) runs for sheriff against the bad guys' candidate and wins the election.
Although Larry "Buster" Crabbe earns top billing, the hero of Drift Fence is former Western star Tom Keene as Jim Travis, who, at a rodeo, meets city dweller Jim Traft, who has come west to erect a fence that will prevent Clay Jackson from continuing his cattle rustling business.
In London, August 1914, Austrian star Elsa Duranyi (Gertrude Michael) and English matinee idol Alan Barclay (Herbert Marshall) are in love and plan an immediate marriage.
Confederate Col. Lafe Harvey (Earl Ross) travels home after the Civil War, where he must tell his niece, Betty (Frances Grant), that her father is presumed dead.
Chet Kasedon is after the Indians hidden gold mine but Chief Moya will not reveal it's location. He has also hired mining engineers Gale and Mortimer to locate the mine.