The film tells the story of two twins separated in childhood who reunite when they are older. One of them has grown between outlaws and has become one of them, a murderous bandit who frightens the region.
After the mysterious death of scientist Dr. Devin Villiers, Det. Frank Turner and his partner are assigned to protect Villiers' colleague, who revealed that a veteran soldier was subjected to an experiment with the objective of creating the ultimate national security weapon.
A late entry in Columbia's seemingly endless Durango Kid Western series, Cyclone Fury was augmented with a hefty dose of stock footage from an earlier Durango effort, Galloping Thunder (1946), footage that included sidekick Smiley Burnette warbling "Hear the Wind (Singing a Cowboy Song)" accompanied by Merle Travis and his Bronco Busters.
A cowboy whose sister has been murdered by a gang of vicious outlaws seeks his revenge. But a venerable old lawman is about to teach the vigilante a lesson about taking the law into one's own hands.
Carmelita and Uncle Matt find themselves in a haunted house, but the "ghosts" are actually enemy agents who are trying to frighten away visitors in order to develop a nitroglycerin bomb.