The simple story has the pair coming to the rescue of peace-loving Mormons when land-hungry Major Harriman sends his bullies to harass them into giving up their fertile valley.
As Bruce Lanning posts a "no trespassing" sign at a watering hole on his Circle A ranch, his sister Jane rides up with news that Wes Caven, the hired gun of the Elwood brothers, is looking for him.
Cole Thornton, a gunfighter for hire, joins forces with an old friend, Sheriff J.P. Harrah. Together with a fighter and a gambler, they help a rancher and his family fight a rival rancher that is trying to steal their water.
Dan Evans, a small time farmer, is hired to escort Ben Wade, a dangerous outlaw, to Yuma. As Evans and Wade wait for the 3:10 train to Yuma, Wade's gang is racing to free him.
When his cattlemen abandon him for the gold fields, rancher Wil Andersen is forced to take on a collection of young boys as his cowboys in order to get his herd to market in time to avoid financial disaster.
Lilli Marlene, a French girl working as a bar maid in her uncle's café in Benghazi, Libya, turns out to be the girl that the popular German wartime song Lili Marleen had been written for before the war, so both the British and the Germans try to use her for propaganda purposes - especially as it turns out that she can sing as well.
Arizona Ranger Larry Grant is posing as an outlaw while hunting for an outlaw gang, secretly led by Lance Corbin, that is stealing silver in Mexico and smelting it into bars for sale in the United States.