On a cross-country Greyhound bus, passengers give historically dubious summaries of major landmarks. Riders include a grieving father of a fallen soldier and C-list celebrities of the 1950s.
A young street vendor who is a cockfighting aficionado, attracted by the image of one of them, settles on the ranch of its owner where he falls in love with the foreman's daughter.
George Nader plays a reporter whose career is ruined by liquor. A comeback opportunity presents itself when Nader is a bystander at the arrest of a well-known criminal.
Dan Evans, a small time farmer, is hired to escort Ben Wade, a dangerous outlaw, to Yuma. As Evans and Wade wait for the 3:10 train to Yuma, Wade's gang is racing to free him.
A mad doctor uses patients at his isolated psychiatric institute as subjects in his attempts to create longevity by surgically installing an artificial gland in their skulls.