Set in a bizarro St. Louis and populated with characters from Palazzolo’s boyhood memories, Caligari’s Cure is an irreverent retelling of Palazzolo’s youth that is both absurd and tender.
Set in Hamburg's “Hell's Kitchen,” a waterfront milieu of gangsters, pimps, dealers and prostitutes, the story follows the attempts of an ex-seaman first to insinuate himself into the scene, and then to extricate himself from it.
The film is inspired by the Mário de Sá-Carneiro short story, where the narration is made by Professor Antena's assistant who walks by his side when he is run over in a perhaps enigmatic way.
A guy picks up a girl hitchhiking and starts making advances to her to sleep with her, albeit with the ruse of offering to do a photo shoot so that she can succeed as a model.
When the 'Lowly Ronin' helps an orphaned teenage girl avoid being turned into a prostitute, she then claims he is her father and they start a farm as father and daughter until fate steps in and he must draw his sword.
When a dedicated jockey finds that the local politicians are not to be trusted and begins to feel his romance with a beautiful woman slowly slipping away, his last-ditch effort to risk it all for his trusted horse Palomo shows that sometimes animals are truly man's best friend.