Merlinda is cursed by her mother after leaving her father on his death bed to be with her rich lover. Abandoned by all she is now pregnant, destitute, and covered in boils. Merlinda gives birth in a cave to a human daughter and a snake son. The baby girl is named Madonna. When Madonna grows up she starts turning into a giant murderous snake. Afraid of losing her lover to the monster she is becoming, Madonna is desperate for answers. Together she and her brother she seek out a cure to their damned existence.
Sixty year old Max is having something of a middle-age crisis. His marriage seems to go nowhere as the passion, tenderness and happiness vanished when their daughter moved out.
Claude, a militant anarchist, is caught stealing and is shot by a policeman while fleeing the scene. Dodo, a hairdresser, is hit by one of the stray bullets.
The boy who wasn't supposed to grow up—Peter Pan—does just that, becoming a soulless corporate lawyer whose workaholism could cost him his wife and kids.
Carmen, a journalist with two children, is on her third marriage, to Antonio, a record producer. Over the course of a year, we follow her through her discontents: Antonio's lateness, his fatigue when she wants to make love, his insistence on her company when she prefers solitude, his treating her work as less important than his, his casual and cruel dismissal of her opinions, her boss assigning her an incompetent editor, bartenders ignoring her, her passage into middle age.
The female group "Die Hard Angels" of the Police Department's Investigation Division 1 begins a physical investigation to destroy a vicious organized crime.