Sobriety, Obesity and Growing Old picks up the narrative and themes begun in Kentridge's first film, Johannesburg the Second Greatest City after Paris, and follows the development of the relationships between his cast of invented characters, Soho Eckstein, his wife and her lover, Felix Teitelbaum. These relationships reflect, metaphorically, the changing political situation in South Africa at the time the film was made. Demonstrations and marches in opposition to the apartheid régime together with the governmental relaxation of most of the State of Emergency regulations and restrictions heralded the beginning of a change in the country's power structure (and white attitudes towards black African rights). Soho, a symbol of South African white power, develops the capacity for awareness, longing and love and the potential for guilt and repentance.
George Banks is an ordinary, middle-class man whose 21 year-old daughter Annie has decided to marry a man from an upper-class family, but George can't think of what life would be like without his daughter.
With the help of a talking freeway billboard, a "wacky weatherman" tries to win the heart of an English newspaper reporter, who is struggling to make sense of the strange world of early-90s Los Angeles.
After developing an addiction to the substance he uses to kill bugs, an exterminator accidentally murders his wife and becomes involved in a secret government plot being orchestrated by giant bugs in an Islamic port town in Africa.