Romeo lives a wealthy lifestyle in Bangalore, India, along with his widowed mother. He had received considerable assistance and encouragement from Raj Mohan to dance and sing, and as a result gets very popular with young women. He meets and is attracted to Madhu, who is also his fan. His mother meets with Madhu's grandfather and both arrange their wedding. Then Romeo finds out that Raj Mohan has been stealing body parts, especially kidneys, from patients in the Satya Moorthy Hospital, and then getting them killed via bus accidents. He meets with Raj and warns him that he is going to expose him publicly. Before he could that Romeo is shot, taken by ambulance, and thrown off of a cliff.
When Ashtray (Shawn Wayans) moves to South Central L.A. to live with his father (who appears to be the same age he is) and grandmother (who likes to talk tough and smoke reefer), he falls in with his gang-banging cousin Loc Dog (Marlon Wayans), who along with the requisite pistols and Uzi carries a thermo-nuclear warhead for self-defense.
Seth Gecko and his younger brother Richard are on the run after a bloody bank robbery in Texas. They escape across the border into Mexico and will be home-free the next morning, when they pay off the local kingpin.
With his gangster boss on trial for murder, a mob thug known as "the Teacher" tells Annie Laird she must talk her fellow jurors into a not-guilty verdict, implying that he'll kill her son Oliver if she fails.