In this science fiction thriller, David Whitman (William Hurt) is a chemist who lost his wife and child in a freak accident and is trying to rebuild his life on his own. While doing research, Whitman discovers a series of mysterious deaths that seem to follow in the path of Joseph Mueller (Peter Weller), a seemingly ordinary man who works as a security guard. Unknown to Mueller, his body carries a strange contaminant that's deadly to many people, and Whitman is desperate to find Mueller and stop him before he can cause more deaths.
In India, open romance is forbidden, as is showing affection in public. A college principal named Narayan is a strong believer in this, aware that a male student named Vicky is in love with Ishika; while another male student is hopelessly in love with Sanjana; and a third man named Karan is in love with a married woman named Kiran.
In Japan, the vampire-hunter Saya, who is a powerful original, is sent by her liaison with the government, David, posed as a teenage student to the Yokota High School on the eve of Halloween to hunt down vampires.
When record store owner Rob Gordon gets dumped by his girlfriend, Laura, because he hasn't changed since they met, he revisits his top five breakups of all time in an attempt to figure out what went wrong.