Ram Chandra is a Tamilian who lives in a shanty hut in Bombay's Dharavi, along with his mom and a younger sister. He dream is to attend school, which he does so, after his sister is loaned out to a beggar to collect alms, but she is unable to withstand hunger for long and passes away. Ram leaves home and subsequently works hard, studies, becomes rich and constructs several colleges to accommodate needy students. One such student he accommodates is a new arrival from Allahabad, Raja, and he arranges his admission in Ram Chandra College for Business Management along with full board and shelter. He also helps Raja sort out his personal problems, including his romance with a young woman he met at the Cyber Café and then at Bandra Railway Station. While Ram Chandra is busy arranging his daughter's marriage with Rajesh Gupta, the only son of a multi-millionaire and educationist, he is quite unaware that the object of Raja's affections is none other than Roja, his very own daughter.
Kunal and Sameer, two straight guys who pretend to be a gay couple to secure an posh Miami apartment, but both of them fall for their gorgeous room-mate Neha, hilarity ensures as they strive to convince one and all they are gay! While secretly trying to win Neha's heart.
When record store owner Rob Gordon gets dumped by his girlfriend, Laura, because he hasn't changed since they met, he revisits his top five breakups of all time in an attempt to figure out what went wrong.
Rocky and Bullwinkle have been living off the finances made from the reruns of their cartoon show. Boris and Natasha somehow manage to crossover into reality and team up with Fearless Leader, an evil criminal turned media mogul with some evil plans up his sleeve.
In Japan, the vampire-hunter Saya, who is a powerful original, is sent by her liaison with the government, David, posed as a teenage student to the Yokota High School on the eve of Halloween to hunt down vampires.