One of the twins is a bus conductor and the other is handicapped. The elder one, Shiva, overhears his parents' plot to kill his mildly retarded brother, Vishnu. He runs away to another city, with his adorable brother, and strives hard to look after Vishnu. As a result of an incident when 'dada' Sundara Moorthy, who runs a beggar trade beats Vishnu brutally, Vishnu becomes handicapped for life. Matters worsen when Sundara Moorthy becomes the chairman of the institute for the physically handicapped. How Shiva deals with the situation forms the rest of the story. Meanwhile Thangam is in love with Shiva, though he does not know this. Later she gives up her love and lets Lavanya marry Shiva.
Mike Sullivan works as a hit man for crime boss John Rooney. Sullivan views Rooney as a father figure, however after his son is witness to a killing, Mike Sullivan finds himself on the run in attempt to save the life of his son and at the same time looking for revenge on those who wronged him.
A rare mutation has occurred within the vampire community - The Reaper. A vampire so consumed with an insatiable bloodlust that they prey on vampires as well as humans, transforming victims who are unlucky enough to survive into Reapers themselves.
Kay and Jay reunite to provide our best, last and only line of defense against a sinister seductress who levels the toughest challenge yet to the MIB's untarnished mission statement – protecting Earth from the scum of the universe.