Thirty-three years ago, an alien force known as the "JAM" invaded Earth through a dimensional portal over Antarctica. Earth's forces managed to drive the JAM away to a distant planet designated as "Fairy". While the majority of Earth's population is unaware of the JAM's presence, the war continues on Fairy, where Rei Fukai is an SAF (Special Air Force) pilot assigned to pilot "Yukikaze"—an advanced reconnaissance fighter plane equipped with a near-sentient A.I. that detects the presence of the JAM within its path.
With the impending ice age almost upon them, a mismatched trio of prehistoric critters – Manny the woolly mammoth, Diego the saber-toothed tiger and Sid the giant sloth – find an orphaned infant and decide to return it to its human parents.
Over the course of three days Ross, a college dropout addicted to crystal-meth, encounters a variety of oddball folks - including a stripper named Nikki and her boyfriend, the local meth producer, The Cook - but all he really wants to do is hook up with his old girlfriend, Amy.
A rare mutation has occurred within the vampire community - The Reaper. A vampire so consumed with an insatiable bloodlust that they prey on vampires as well as humans, transforming victims who are unlucky enough to survive into Reapers themselves.