"On the Road" has neither script nor narration. It only includes music and percussion by Nana Vasconcelos and Ralph Towner, as well as singing and lute music by a blind woman. The counterpoint and interweaving of these passages in time seem to communicate the transmigration of life and the flow of time. Birth and death move in a cycle like the eternal earth, and people can only constantly walk along the road.
The story follows the two sisters Melissa and Emily, the former who accidentally killed her husband Alan and the latter who agrees to help her bury her husband in the desert.
A group of actors is shooting a film in Aguas Buenas, based on the legend of a magician. There, they become infected with the honesty syndrome, which unleashes a number of hidden secrets to come to light.
Toyotomi Hideyori's married granddaughter, Princess Sen, is targeted by someone. Hattori Hanzo, who receives the news, challenges the blocking of conspiracy to recover Senhime.
A socially awkward young woman gets bitten by a radioactive spider and becomes a crime-fighting superhero and tries to defeat a nefarious super villain while going after any man (or woman) she wants to bed down with.
When Isabelle and Theo invite Matthew to stay with them, what begins as a casual friendship ripens into a sensual voyage of discovery and desire in which nothing is off limits and everything is possible.