Lisa is a middle-class white woman from Toronto, Canada. She's also addicted to crack cocaine. To maintain her habit, she works as a prostitute while living in a hotel room.
In the 1920s, former coal miner Harry Hoxsey claimed to have an herbal cure for cancer. Although scoffed at and ultimately banned by the medical establishment, by the 1950s, Hoxsey's formula had been used to treat thousands of patients, who testified to its efficacy.
The single mother Leonie has great worries: Since her ex-boyfriend left her a huge debt mountain, knows the young cosmetics saleswoman hardly how to make a living.
Emma (Damasus-Aboderin), Candace (Genevieve Nnaji) and Yvonne (Jalade-Ekeinde) have been friends since High School and have since settled into their respective lifestyles.
After terrorizing the people of Nodaway County and repeatedly escaping justice for years, the town bully finally meets his demise at the hands of the townspeople of Skidmore, Missouri.