Franky B and Dane are partners in crime - they kill for the money. Their former colleague, Jeremy, has decided to quit the business, taking with him an insurance policy in the form of a disc containing all their business information. The race is on as Frank B, Dane and more battle time and each other to retrieve the disc.
Chaos reigns at the natural history museum when night watchman Larry Daley accidentally stirs up an ancient curse, awakening Attila the Hun, an army of gladiators, a Tyrannosaurus rex and other exhibits.
In Tokyo, a young woman is exposed to the same mysterious curse that afflicted her sister. The supernatural force, which fills a person with rage before spreading to its next victim, brings together a group of previously unrelated people who attempt to unlock its secret to save their lives.
Edward Wilson, the only witness to his father's suicide and member of the Skull and Bones Society while a student at Yale, is a morally upright young man who values honor and discretion, qualities that help him to be recruited for a career in the newly founded OSS.
To test its top-secret Human Hibernation Project, the Pentagon picks the most average Americans it can find - an Army private and a prostitute - and sends them to the year 2505 after a series of freak events.