The story starts in a jail, where prisoner Muthupandi (Prabhu) is being interrogated by a police officer (Vijayakumar) about his past. Without hesitation, Muthupandi tells. Muthupandi is a son of the soil, a very hard working self-made man who dotes on his only sister Kavitha (Trisha Krishnan). Their mother died very early and it was Muthupandi who brought up Kavitha with a lot of love and affection. Kavitha’s best friend Lalitha (Richa Pallod), who is getting married, takes Kavitha to her house for the nuptial ceremony. As an emotional scene prior to this notes, this is the first time Kavitha has been away from her brother.
Chaos reigns at the natural history museum when night watchman Larry Daley accidentally stirs up an ancient curse, awakening Attila the Hun, an army of gladiators, a Tyrannosaurus rex and other exhibits.
During a trip to Germany to scatter their grandfather's ashes, German-American brothers Todd and Jan discover Beerfest, the secret Olympics of downing stout, and want to enter the contest to defend their family's beer-guzzling honor.
In Tokyo, a young woman is exposed to the same mysterious curse that afflicted her sister. The supernatural force, which fills a person with rage before spreading to its next victim, brings together a group of previously unrelated people who attempt to unlock its secret to save their lives.
A man receives a mysterious e-mail appearing to be from his wife, who was murdered years earlier. As he frantically tries to find out whether she's alive, he finds himself being implicated in her death.