Chaos reigns at the natural history museum when night watchman Larry Daley accidentally stirs up an ancient curse, awakening Attila the Hun, an army of gladiators, a Tyrannosaurus rex and other exhibits.
In Tokyo, a young woman is exposed to the same mysterious curse that afflicted her sister. The supernatural force, which fills a person with rage before spreading to its next victim, brings together a group of previously unrelated people who attempt to unlock its secret to save their lives.
Everyone deserves a chance to follow their dreams, but some people only get one shot. Tyler Gage is a rebel from the wrong side of Baltimore's tracks and the only thing that stands between him and an unfulfilled life are his dreams of one day making it out of there.
Jigsaw has disappeared. Along with his new apprentice Amanda, the puppet-master behind the cruel, intricate games that have terrified a community and baffled police has once again eluded capture and vanished.