The story takes place in a port controlled by Charlie the Greek and his criminal band. There are two things Charlie hates: drugs and homosexuality. But both are part of his life: he is madly in love with Joy who is a junkie, though he denies it even to himself. And regarding the homosexuality issue, his right hand, Tony, has an amorous relationship with a transsexual who is part of a group of trans-prostitutes. Ignoring Charlie's adamant orders, the transvestites work the streets around the port, with the help of Tony, who secretly supports them
When reporter Jean Craddock interviews Bad Blake -- an alcoholic, seen-better-days country music legend -- they connect, and the hard-living crooner sees a possible saving grace in a life with Jean and her young son.
B-Dawg, Mudbud, Budderball, and all the rest of the Buddies are back, but this time, they're setting their sights even higher -- as in, the moon! With the help of their new pals Spudnick (voiced by Jason Earles) and Gravity, these pooches are go for launch.
Aliens land in South Africa and, with their ship totally disabled, have no way home. Years later, after living in a slum and wearing out their welcome the 'Non-Humans' are being moved to a new tent city overseen by Multi-National United (MNU).